Thanks to infrastructure grants from LU, the faculties of Science and Medicine, we can now make the latest MicroScale Thermophoresis (MST) and Spectral Shift (SpS) equipment available to users.
The Monolith X allows in-depth interaction and binding studies between a labeled target and a ligand, for example to determine the dissociation constant (Kd) or the effective concentration (EC50) in a protein-protein interaction, within the nM to µM range. A wide range of molecules can be tested: proteins (even membrane proteins or large protein complexes), small molecules or ions…etc
For more information about the system , please visit the Monolith X webpage (external homepage). Information regarding access and user fees is found in the biophysics and crystallisation section here at the LP3 website.